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LCB 03-0110 Dihydrochloride 是BTK 和SYK 家族以及DDR2家族中c-Src 激酶(IC50=1.3 nM)和酪氨酸激酶的有效抑制剂。在体外抑制LPS 诱导的巨噬细胞活化和TGF-β1诱导的成纤维细胞活化,抑制巨噬细胞和成纤维细胞的活化,并抑制伤口愈合模型中的瘢痕形成。
LCB 03-0110 Dihydrochloride 是BTK 和SYK 家族以及DDR2家族中c-Src 激酶(IC50=1.3 nM)和酪氨酸激酶的有效抑制剂。在体外抑制LPS 诱导的巨噬细胞活化和TGF-β1诱导的成纤维细胞活化,抑制巨噬细胞和成纤维细胞的活化,并抑制伤口愈合模型中的瘢痕形成。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 478 | 现货 | |
2 mg | ¥ 714 | 现货 | |
5 mg | ¥ 1,090 | 现货 | |
10 mg | ¥ 1,590 | 现货 | |
25 mg | ¥ 2,670 | 现货 | |
50 mg | ¥ 3,790 | 现货 | |
100 mg | 询价 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,190 | 现货 |
产品描述 | LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-β1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models. |
体外活性 | LCB 03-0110处理TGF-β1和I型胶原暴露的细胞时,特别显著地抑制了酪氨酸861的磷酸化,1μM浓度下可使其降低约50%,而3μM浓度几乎完全抑制。 |
分子量 | 490.45 |
分子式 | C24H25Cl2N3O2S |
CAS No. | 1962928-28-4 |
Smiles | Cl.Cl.Oc1cccc(Nc2ccnc3cc(sc23)-c2cccc(CN3CCOCC3)c2)c1 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 30 mg/mL (61.17 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
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